Intravascular temperature monitoring system

ABSTRACT

A system for monitoring one or more temperatures at a vessel wall of a vessel of a patient includes an optical fiber, an optical read-out mechanism, and a therapeutic device. The optical fiber may be deployed along an extent of the vessel and may include one or more fiber Bragg grating (FBG) temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber. The optical read-out mechanism may be optically coupled to the optical fiber, and it may be configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors. The detected light reflected from the one or more FBG temperature sensors may encode local temperatures at each of the one or more corresponding sensor locations. The therapeutic device may be configured for performing a therapeutic procedure to or through the vessel wall.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority under 35 U.S.C. §119 to U.S. Provisional Application Ser. No. 61/545,959, filed Oct. 11, 2011, the entirety of which is incorporated herein by reference.

TECHNICAL FIELD

The present disclosure relates to optical fiber-based sensor systems, and more particularly, optical fiber-based methods and apparatus for monitoring temperatures within vessels of a patient. Such monitoring may be performed in conjunction with ablation of nerve tissue proximal a blood vessel wall of the patient.

BACKGROUND

Certain treatments require the temporary or permanent interruption or modification of select nerve function. One example treatment is renal nerve ablation which is sometimes used to treat conditions related to congestive heart failure. The kidneys produce a sympathetic response to congestive heart failure, which, among other effects, increases the undesired retention of water and/or sodium. Ablating some of the nerves running to the kidneys reduces or eliminates this sympathetic function, which provides a corresponding reduction in the associated undesired symptoms.

Many nerves (and nervous tissue such as brain tissue), including renal nerves, run along the walls of or in close proximity to blood vessels and thus can be accessed intravascularly through the walls of the blood vessels. It is therefore desirable to provide for systems and methods for intravascular nerve modulation. It may be desirable to monitor temperatures intravascularly at vessel wall locations before, during, and/or after some such procedures. Minimally invasive in vivo temperature measurement may find uses in other medical contexts as well. Therefore, there remains room for improvement and/or alternatives in providing for systems and methods for intravascular nerve modulation.

SUMMARY

The present disclosure relates to optical fiber-based sensor systems, and more particularly, optical fiber-based methods and apparatus for monitoring temperatures within vessels of a patient. In one illustrative embodiment, a system for monitoring one or more temperatures at a vessel wall of a vessel of a patient includes an optical fiber, an optical read-out mechanism, and a therapeutic device. The optical fiber may be deployed along an extent of the vessel and may include one or more fiber Bragg grating (FBG) temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber. The optical read-out mechanism may be optically coupled to the optical fiber, and it may be configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors. The detected light reflected from the one or more FBG temperature sensors may encode local temperatures at each of the one or more corresponding sensor locations. The therapeutic device may be configured for performing a therapeutic procedure to or through the vessel wall.

In another illustrative embodiment, an intravascular nerve ablation system includes a helical structure deployed along an extent of a vessel of a patient and an optical fiber attached to the helical structure and following a helical path of the helical structure. The optical fiber may have one or more fiber Bragg grating temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber. The helical structure may maintain at least some of the one or more FBG temperature sensors in thermal contact with a wall of the vessel.

In yet another illustrative embodiment, a method for monitoring one or more temperatures at a vessel wall of a vessel of a patient with an optical fiber having one or more fiber Bragg grating temperature sensors is provided. The method includes the steps of deploying the optical fiber along an extent of the vessel such that the optical fiber is disposed against the vessel wall with the one or more FBG temperature sensors in thermal contact with the vessel wall, and reading-out temperatures detected by the one or more FBG temperature sensors with an optical read-out mechanism configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors. The method may further include the step of performing a therapeutic procedure with a therapeutic device disposed within the vessel proximal to at least one of the one or more FBG temperature sensors. The therapeutic procedure may include tissue ablation. In some instances, a temperature measured by the at least one of the one or more FBG temperature sensors may be used as a feedback signal for controlling the therapeutic procedure.

The above summary of some embodiments is not intended to describe each disclosed embodiment or every implementation of the present disclosure. The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments.

BRIEF DESCRIPTION OF THE DRAWINGS

The disclosure may be more completely understood in consideration of the following detailed description of various embodiments in connection with the accompanying drawings, in which:

FIG. 1 is a schematic view of an intravascular temperature monitoring system and a renal nerve modulation system in situ.

FIG. 2 is a schematic illustration of elements of an optical fiber-based sensor system.

FIG. 3 is a schematic illustration of elements of an optical fiber-based sensor system deployed in a vessel.

FIG. 4 is a schematic cross-sectional view of a system including a support structure with an integrated optical fiber and a movable therapeutic device.

FIG. 5 is a schematic illustration of a distal end of a renal nerve ablation system with off-wall ablation electrodes and an optical fiber-based sensor.

FIG. 6 is a flowchart of an exemplary optical fiber-based temperature measuring method.

While the disclosure is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure.

DETAILED DESCRIPTION

For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.

All numeric values are herein assumed to be modified by the term “about”, whether or not explicitly indicated. The term “about” generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (i.e., having the same function or result). In many instances, the term “about” may be indicative as including numbers that are rounded to the nearest significant figure.

The recitation of numerical ranges by endpoints includes all numbers within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).

Although some suitable dimensions, ranges and/or values pertaining to various components, features and/or specifications are disclosed, one of skill in the art, incited by the present disclosure, would understand desired dimensions, ranges and/or values may deviate from those expressly disclosed.

As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same. The detailed description and the drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the disclosure. The illustrative embodiments depicted are intended only as exemplary. Selected features of any illustrative embodiment may be incorporated into an additional embodiment unless clearly stated to the contrary.

The present disclosure pertains at least in part to an optical method of temperature measurement that may be performed in vivo. Temperature measurements at point(s) of treatment may be useful in assessing, monitoring, and/or controlling a variety of medical procedures, including ablative procedures that rely on raising and/or lowering the temperature of tissue to achieve ablative effects. Systems and methods of the present disclosure may be employed in conjunction with intravascular nerve ablation procedures, but they may generally find utility in any number of other medical scenarios, as will be readily appreciated by those skilled in the art.

Nerves that lie in proximity to blood vessels often run along the length of a section of a blood vessel. Nerves are difficult to image using standard imaging techniques such as radiography. Therefore, it may be desirable to apply the ablation or other nerve modulation procedure at different radial locations on the vessel wall to achieve ablation around the complete circumference of the vessel wall. It may also be desirable to apply the procedure at different longitudinal locations so as to avoid weakening or otherwise affecting the vessel wall along a single circumferential section. Systems and methods of the present disclosure may be employed to make temperature measurements proximal to ablation treatment locations as described.

By way of a general introduction and orientation, FIG. 1 is a schematic view illustrating a system for monitoring one or more temperatures at a vessel wall of a vessel of a patient, as well as a renal nerve modulation system. In some illustrative embodiments, the temperature monitoring system and nerve modulation system may be considered parts of a single integrated system.

The temperature monitoring system includes an optical fiber 10 that includes one or more fiber Bragg grating (FBG) temperature sensors (not shown in FIG. 1) disposed at one or more corresponding sensor locations along a length of the optical fiber. At a proximal end, the optical fiber 10 may be optically coupled to an optical read-out mechanism 12. The optical fiber 10 may be attached to and/or integrated with a support structure 14. Support structure 14 may be deployed within at least one vessel of a patient along an extent of the vessel, where it may substantially fix the optical fiber 10 within the vessel. As suggested schematically in FIG. 1, at a distal region 16 the optical fiber 10 may be deployed along an extent of the vessel in a helical path, although other deployment paths are contemplated. The support structure 14 may be deployed in the same helical path as optical fiber 10, although this is not necessary, even in cases where the optical fiber is deployed in a helical path.

FIG. 1 illustrates elements of a renal nerve modulation system which may be used in concert with the temperature monitoring system, although either system may be practiced independently of the practice or presence of the other system. The renal nerve modulation system may include an elongate conductor 18, which may be coupled to a movable ablation tip (not shown) in the distal region 16. Conductor 18 may be coupled to an ablation controller 20, which may supply electrical energy to the movable ablation tip in distal region 16. Return electrode patches 22 optionally may be supplied on the legs or at another conventional location on the patient's body to complete the circuit.

FIG. 2 is a schematic illustration of elements of an optical fiber-based sensor system 200, which may share features with the temperature monitoring system of FIG. 1. System 200 includes an optical fiber 202, which may be optically coupled to an optical read-out mechanism 204. Optical fiber includes one or more fiber Bragg gratings (FBGs) 206′-206″″ (collectively, 206). FIG. 2 is a simplified, schematic illustration and does not necessarily depict all of the technical features of an optical fiber with FBGs, as would be understood by one of ordinary skill in the art. For example, optical fiber 202 may include a core, cladding, and any other suitable layers, such as a buffer coating, protective housing, etc. Fiber Bragg gratings of the present disclosure, such as FBGs 206 of optical fiber 202, may be formed by any suitable method, such as via two-beam interference, phase or photo masking, point-by-point writing by laser, and so on.

A FBG generally may include variations in refractive index in the core of the fiber. The refractive index variations may form a wavelength-specific grating mirror that reflects essentially all or a portion of the light at a specific reflection wavelength, while allowing the balance of light propagating in the fiber to pass. The reflection wavelength of a FBG may shift from its nominal value due to local conditions of the optical fiber at the FBG, such as (but not necessarily limited to) temperature and strain. Temperature and/or strain may each affect the refractive index and/or grating period of the FBG, resulting in a reflection wavelength shift. This effect may be exploited to form a FBG sensor. While a FBG may generally respond (in wavelength shift) to both temperature and strain, a FBG may be packaged (e.g., housed) in order to modulate the physical conditions observed at the FBG. For example, a FBG may be packaged in order to decouple the FBG from bending, tension, compression, torsion, or other forces. With a nearly negligible temperature coefficient of expansion of the fiber (for a glass fiber), changes in reflection wavelength for a FBG so-packaged may be attributed primarily to a change in refractive index of the fiber caused by temperature changes. In FIG. 2, packaged FBG sensors are represented by 208′-208″″.

In another sensor example, a FBG may be packaged in such a way that the packaging or housing couples changes in pressure into stress in the fiber, leading to a predictable shift in reflection wavelength. Other sensors are contemplated. A FBG chemical sensor, for example, may include a FBG housing incorporating a chemically-sensitive substrate. In general, any physical mechanism that translates a change in a physical quantity into a change in FBG reflection wavelength may potentially be used as the basis for a FBG sensor. Multiple FBG sensors (e.g., 208′-208″″) may be manufactured on a single optical fiber (e.g., 202) such that each FBG sensor has a unique reflection wavelength. Such wavelength division multiplexing makes it possible to differentiate between reflection signals from a plurality of FBG sensors 208′-208″″ on a single optical fiber 202. To avoid ambiguity in interpreting FBG reflection signals, it may be desirable to fabricate each FBG to reflect within its own dedicated wavelength band wide enough to accommodate physically-induced reflection wavelength shifts (that encode signal information) as well as the intrinsic non-zero width of the non-shifted reflection distribution. Typically, FBG temperature sensors may be allocated an approximately 1 nm wide range, while FBG strain sensors may be allocated an approximately 5 nm wide range. Wider or narrower ranges may be employed, as appropriate.

FBG sensors 208′-208″″ having unique reflection wavelengths may be formed at distinct locations along optical fiber 202, such that each particular reflected wavelength may then correspond to a specific sensor location along the optical fiber.

In some cases, shifts in reflection wavelength from multiple FBG sensors may be interpreted in combination to arrive at a physical measurement. For example, a temperature reading from a FBG temperature sensor may be used to calibrate a pressure reading from a FBG pressure sensor, which by itself may be sensitive to both temperature and pressure changes. In the present disclosure, a FBG sensor may incorporate one or more fiber Bragg gratings to achieve measurement of a physical quantity.

A device such as optical read-out mechanism 204 (and 10 of FIG. 1) may be employed to measure the wavelength reflected by a FBG sensor 208 of optical fiber 202. Optical read-out mechanism 204 may include any suitable light source 210 which may transmit light into the optical fiber 202 via an optical coupler 212. While optical coupler 212 is illustrated schematically to suggest a partially-reflective mirror or beam-splitter, any suitable optical coupler may be used. Light propagates down the optical fiber 202 and is selectively reflected by one or more fiber Bragg gratings at their specific reflection wavelengths. The specific reflection wavelengths may encode information about conditions at the FBG sensor 208, such as temperature, pressure, etc. Reflected light returns up the optical fiber 202 back to the optical read-out mechanism 204, where optical coupler 212 may direct the reflected light to detector 214. Detection of light reflected by FBG sensors 208, including determination of reflection wavelengths, may then be interpreted by other components (not shown) of the optical read-out mechanism 204 (or external to the optical read-out mechanism) in order to arrive at the desired quantities measured by the FBG sensors 208.

A number of different light source 210/detector 214 combinations may be employed in an optical read-out mechanism 204. In one illustrative embodiment, a broadband continuous light source may be used in conjunction with a dispersive element that distributes various wavelength components of the reflected light to different locations on a detector array. In another illustrative embodiment, a tunable laser is swept over a range of wavelengths, and a photodetector measures the intensities of reflected light corresponding to the wavelengths provided by the laser at given sweep times. Other light source and detector combinations are contemplated, and any suitable combination of light source 210 and detector 214 may be employed in optical read-out mechanism 204. Some current technologies may be able to resolve reflected wavelength shifts on the order of a single picometer, which may translate to temperature measurement resolution on the order of 0.1 degree Celsius. In some cases, temperature measurement resolutions on the order of 0.03 degree Celsius may be achievable.

Optical fiber-based sensor systems of the present disclosure may be deployed in vivo in any suitable manner, and may be highly compatible with minimally-invasive techniques. FIG. 3 is a schematic illustration of elements of an optical fiber-based sensor system deployed in a vessel 302. Elements of the system of FIG. 3 may be similar to or the same as corresponding elements of FIGS. 1 and 2. In the illustrative embodiment of FIG. 3, component 304 is an optical fiber integrated with a support structure. In some other illustrative embodiments, an optical fiber may be attached to, but not necessarily be integrated with, a support structure.

Support structure with integrated optical fiber 304 may be configured to compact for delivery into the vessel 302, and expand for deployment in the vessel. The system may include any suitable components to facilitate delivery of optical fiber/support structure 304 to a target location in vessel 302 and deployment at the target location. Such delivery/deployment components may include (but are not necessarily limited to) a delivery catheter 308, which may be advanced from an entry site to the target location, and a sheath 310, which may surround structure 304 and maintain it in a compact configuration during delivery, then be withdrawn to allow expansion and fixation of the support structure and optical fiber. Structure 304 may be self-expanding or may be expanded through the use of a balloon, pull wire or the like.

Any suitable material may be used for the support structure. In some illustrative embodiments, the support structure may be fabricated from non-conducting polymers.

Optical fiber/support structure 304 may be deployed along an extent of vessel 302 in a helical path. In the illustrative embodiment of FIG. 3, the support structure has a helical shape, and the optical fiber is attached to the support structure and follows the helical shape of the support structure. In some other illustrative embodiments, the support structure may not have a helical shape, but the optical fiber may be attached to the support structure and itself follow a helical path. The support structure may substantially fix the optical fiber within vessel 302. FBG sensors 306 may be distributed along a length of the optical fiber of component 304. The support structure may fix the one or more FBG sensors 306 against the wall of vessel 302 such that at least one, some, or all of the one or more FBG sensors is in effective contact with the vessel wall at its corresponding sensor location. In the context of a FBG temperature sensor, for example, “effective contact” may mean thermal contact. In the context of a FBG pressure sensor, “effective contact” may mean mechanical contact.

At least some of the FBG sensors 306 may be substantially equally-spaced-apart along the optical fiber such that, in combination with the helical path along which the optical fiber is deployed, the plurality of FBG sensors are disposed around the vessel with substantially equal angular displacements between adjacent FBG sensors. The angular displacement between adjacent FBG sensors is schematically illustrated in FIG. 3 as the angle θ. The FBG sensors 306 may be spaced such that 0 has a value of about 90, 60, 45, 30, or 120 degrees, or any other suitable value. The helical path followed by the optical fiber/support structure 304 may have any suitable pitch (indicated in FIG. 3 by “p”). In some illustrative embodiments, the pitch may be between about 5 mm to about 15 mm.

The system of FIG. 3 may also include a therapeutic device 312 for performing a therapeutic procedure to or through the wall of vessel 302. Therapeutic device 312 may be any suitable device. In some illustrative embodiments, therapeutic device 312 is a movable ablation tip, which may be an RF ablation tip. Therapeutic device 312 may be attached to a cable 314, which may be a conductor like elongate conductor 18 of FIG. 1. Cable 314 may also serve as a pull wire for applying mechanical force to therapeutic device 312, by which means the device may be repositioned. Support structure 304 may be configured to guide motion of the therapeutic device 312 on a path adjacent the wall of the vessel 302 along at least part of an extent of the vessel. For example, the support structure 304 of the present disclosure may take the form of a helical “rail” support system for guiding an optical fiber-based sensor system.

FIG. 4 is a schematic cross-sectional view of a system including a support structure 402 with an integrated optical fiber 404, the features of which may be the same or similar in part or in whole with those of the systems of FIGS. 1 and 3. Optical fiber 404 includes at least one FBG sensor 406. FBG sensor 406 generally may displace a larger cross-sectional area than the optical fiber 404 alone. Support structure 402 may integrally house the optical fiber 404 and one or more FBG sensors 406 such that the support structure, optical fiber, and FBG sensors present a substantially constant cross-section along a length of the support structure. A substantially constant cross-section may assist in deploying or otherwise positioning the integrated support structure 402 and optical fiber 404. The support structure 402 with integrated optical fiber 404 and FBG sensor(s) 406 may have a substantially constant catheter size of about 0.5 mm, 0.8 mm, 1.0 mm, or about 1, 1.5, 2, 2.5, 3, or 4 Fr. FBG sensors maybe about 1, 2, 3, or 4 mm in length along the fiber. Radiopaque markers may be incorporated into the support structure to aid localization of the FBG sensors.

Support structure 402 may include a groove 408, protrusion, or other structure(s) to facilitate slidable attachment of a therapeutic device 410, which may have a mating element 412 corresponding to groove 408. With such features, therapeutic device 410 may be made to slide longitudinally along the support structure, following its path (helical or otherwise). In such a way, the therapeutic device 410 may be positioned in one or more treatment locations. The support structure 402 may be configured such that the position of the therapeutic device 410 is maintained relative to the vessel wall 414 such that the therapeutic device may function effectively, at least at the one or more treatment locations. This may include maintaining mechanical, thermal, or any other type of contact between the therapeutic device 410 and the wall 414. In some illustrative embodiments, the support structure 402 may be configured such that the therapeutic device 410 is moved out of contact with the wall 414 between treatment locations, and in contact only at treatment locations. In some illustrative embodiments, FBG sensors may be provided proximal (with a specified positional relationship) to some or all treatment locations such that the FBG sensor may provide measurements related to the therapy. In some illustrative embodiments, at least one FBG sensor is provided proximal to each treatment location. In some illustrative embodiments, the therapeutic device 410 is an ablation tip, and the support structure 402 may be configured such that the ablation tip ablates tissue within a specified distance of a FBG temperature sensor. The specified distance may be about 1, 2, or 3 mm. The specified distance may be within an effective ablation radius of the ablation tip, which may be about 3 mm.

Systems and methods for optical fiber-based sensing can provide robust real-time in vivo measurement capabilities for medical procedures. For example, in a system like that of FIGS. 3 and 4, therapeutic device 312, 410 may be an RF ablation tip and the FBG sensors 306/406 may be temperature sensors. Having a real-time temperature sensor proximal to a treatment location may allow a clinician to verify that ablation energy is being delivered to tissue as intended, for example, by observing that an expected temperature rise is observed. (Similarly, a temperature drop due to cryo-ablation could be observed.) The combination of temperature measurement capability along with knowledge of the locations of the FBG temperature sensors may provide the ability to confirm the position of the ablation tip. In some illustrative embodiments, a system and/or method may use information provided by a FBG sensor for real-time feedback control of a therapeutic procedure. For example, in an RF ablation procedure performed with the apparatus of FIG. 1, a temperature measurement from a FBG temperature sensor may be used as a feedback signal for ablation controller 20, which may modulate the electrical energy delivered to the ablation tip via conductor 18. The energy could, for example, be increased such that it is sufficient to heat tissue to at least a minimum effective temperature for ablation, but also limited such that it does not overheat tissue. A typical ablation temperature may be, for example, about 60 degrees Celsius. Temperature resolutions achievable by FBG temperature sensor system may depend on various factors, such as the type of optical read-out mechanism used. In some instances, resolutions of 0.1 degrees Celsius may be measured. Lower resolutions, such as 0.5 or 1 degree Celsius, may be obtainable with less costly equipment, and may be sufficient for therapeutic monitoring.

In some illustrative embodiments, an optical fiber-based sensing system may include more than one type of FBG sensor on a single optical fiber. For example, a single optical fiber may include both FBG temperature sensors and FBG pressure sensors. In a renal nerve ablation procedure or another procedure in which lowering blood pressure is a desired outcome, a FBG pressure sensor could allow a real-time, local blood pressure measurement to be made immediately before, during, and after a procedure. The typical responsiveness of blood pressure to the nerve ablation therapy may not be known, but such a pressure sensor could permit the response to be characterized in the actual patient undergoing treatment. In some illustrative embodiments, leaving an optical fiber with FBG sensors in situ following an ablation procedure is contemplated (perhaps particularly feasible in cases where the fiber and support structure are independent of ablation hardware), making longer term monitoring of blood pressure at a particular vascular location practicable. With an optical fiber left in situ, it is contemplated that ablation hardware may be reintroduced into the vessel at a later time for a follow-up procedure. If the optical fiber is fixed in the original position, then it may be possible to obtain precise knowledge various old and new therapy locations via the fixed FBG sensors.

Fiber optic-based sensor systems may be fabricated without the use of metals or other conductors. Accordingly, they may be compatible with magnetic resonance imaging and other medical procedures for which the presence of conductors may present issues. Their dependence on optics for their operation can eliminate electromagnetic interference (at non-optical frequencies) as a potential problem.

Other configurations for optical fiber-based sensor systems are contemplated. FIG. 5 is a schematic illustration of a distal end of a renal nerve ablation system with ablation electrodes 502 that, when deployed, are maintained in positions spaced-apart from the vessel wall (not shown). In the embodiment of FIG. 5, an optical fiber 504 is attached to and wraps around the device such that FBG temperature sensors 506 are placed where, upon deployment, they may be disposed in thermal contact with a vessel wall between the wall and each ablation electrode 502 so that they may be used to monitor temperatures during an ablation procedure.

FIG. 6 is a flowchart of an exemplary optical fiber-based temperature measuring method 600, such as may be performed with devices of the present disclosure. At 610, an optical fiber with FBG temperature sensors is deployed in a vessel. At 620, temperatures detected by FBG temperature sensors are read out over the optical fiber. Optionally, at 630, tissue is ablated proximal to one or more FBG temperature sensors. In some other illustrative embodiments, other therapeutic actions may be performed. Optionally at 640, the ablation equipment is controlled with feedback (e.g,, measured temperatures) from the FBG temperature sensors. In some other illustrative embodiments, other therapeutic actions may be controlled with feedback from FBG sensors, which may be sensors other than temperature sensors.

Those skilled in the art will recognize that the present disclosure may be manifested in a variety of forms other than the specific embodiments described and contemplated herein. Accordingly, departure in form and detail may be made without departing from the scope and spirit of the present disclosure as described in the appended claims. 

What is claimed is:
 1. A system for monitoring one or more temperatures at a vessel wall of a vessel of a patient, the system comprising: an optical fiber deployed along an extent of the vessel, the fiber including one or more fiber Bragg grating (FBG) temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber; an optical read-out mechanism optically coupled to the optical fiber, the optical read-out mechanism configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors, the detected light reflected from the one or more FBG temperature sensors encoding local temperatures at each of the one or more corresponding sensor locations; and a therapeutic device for performing a therapeutic procedure to or through the vessel wall.
 2. The system of claim 1, further comprising a support structure deployed within the vessel along the extent of the vessel, wherein the support structure substantially fixes the optical fiber within the vessel.
 3. The system of claim 2, wherein the support structure is configured to compact for delivery into the vessel, and expand for deployment in the vessel.
 4. The system of claim 2, wherein the support structure further fixes the one or more FBG temperature sensors against the vessel wall such that each of the one or more FBG temperature sensors is in thermal contact with the vessel wall at its corresponding sensor location.
 5. The system of claim 2, wherein the support structure has a helical shape, and the optical fiber is attached to the support structure and follows the helical shape of the support structure.
 6. The system of claim 5, wherein the optical fiber and one or more FBG temperature sensors are integrally housed by the support structure such that the support structure, optical fiber, and one or more FBG temperature sensors present a substantially constant cross-section along a length of the support structure.
 7. The system of claim 2, wherein the therapeutic device includes a movable ablation tip, wherein the support structure is configured to guide motion of the ablation tip on a path adjacent the vessel wall along at least part of the extent of the vessel.
 8. The system of claim 7, further comprising a controller for the movable ablation tip, wherein detected light reflected from one or more FBG temperature sensors provides information for a feedback signal used by the controller in controlling the movable ablation tip.
 9. The system of claim 7, wherein the support structure is configured such that the movable ablation tip is movable on the path to at least one treatment location where the ablation tip ablates tissue within about 2 mm of one of the one or more FBG temperature sensors.
 10. The system of claim 1, wherein the optical fiber is deployed along the extent of the vessel in a helical path.
 11. The system of claim 10, wherein the one or more FBG temperature sensors include a plurality of FBG temperature sensors substantially equally-spaced-apart along the optical fiber such that, in combination with the helical path along which the optical fiber is deployed, the plurality of FBG temperature sensors are disposed around the vessel with substantially equal angular displacements between adjacent FBG temperature sensors.
 12. The system of claim 11, wherein the substantially equal angular displacements between adjacent FBG temperature sensors are about 90 degrees.
 13. The system of claim 11, wherein the substantially equal angular displacements between adjacent FBG temperature sensors are about 60 degrees.
 14. The system of claim 10, wherein the pitch of the helical path is between about 5 mm to about 15 mm.
 15. The system of claim 1, wherein the optical fiber includes at least one FBG sensor other than the one or more FBG temperature sensors.
 16. An intravascular nerve ablation system comprising: a helical structure deployed along an extent of a vessel of a patient; and an optical fiber having one or more fiber Bragg grating (FBG) temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber, the optical fiber being attached to the helical structure and following a helical path of the helical structure, the helical structure maintaining at least some of the one or more FBG temperature sensors in thermal contact with a wall of the vessel.
 17. The system of claim 16, further comprising an ablation element slidingly attached to the helical structure and movable along the helical structure between treatment locations, each treatment location being proximal one of the one or more FBG temperature sensors.
 18. A method for monitoring one or more temperatures at a vessel wall of a vessel of a patient with an optical fiber having one or more fiber Bragg grating (FBG) temperature sensors, the method comprising: deploying the optical fiber along an extent of the vessel such that the optical fiber is disposed against the vessel wall with the one or more FBG temperature sensors in thermal contact with the vessel wall; and reading-out temperatures detected by the one or more FBG temperature sensors with an optical read-out mechanism configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors.
 19. The method of claim 18, wherein the optical fiber is integrated with a helical support structure that maintains the position of the optical fiber in the vessel and positions the FBG temperature sensors against the vessel wall.
 20. The method of claim 18, further comprising the step of performing a therapeutic procedure with a therapeutic device disposed within the vessel proximal to at least one of the one or more FBG temperature sensors and wherein performing the therapeutic procedure includes ablating tissue. 